Mayor Gavin Newsom has said the route of the Olympic torch "will continue to change" from the published course to a new route.
UPDATE:
Here is the CBS 5 raw video of Mayor Newsom talking about a course change for Wednesday.
And here's a rough transcript:
"The bottom line is we've said from Day One, we will continue to adapt. This route is not fixed. It will continue to change. It will change up until that torch is passed--potentially through even the middle of the relay."
UPDATE #2: A commenter notes that the initial wording of this post was misleading, and on re-reading the entry I agree. The inaccuracies were not intentional. Changes have been made to the post to make it more accurate.